Ontology highlight
ABSTRACT:
SUBMITTER: Jhunjhunwala S
PROVIDER: S-EPMC2771211 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Jhunjhunwala Suchit S van Zelm Menno C MC Peak Mandy M MM Cutchin Steve S Riblet Roy R van Dongen Jacques J M JJ Grosveld Frank G FG Knoch Tobias A TA Murre Cornelis C
Cell 20080401 2
The immunoglobulin heavy-chain (Igh) locus is organized into distinct regions that contain multiple variable (V(H)), diversity (D(H)), joining (J(H)) and constant (C(H)) coding elements. How the Igh locus is structured in 3D space is unknown. To probe the topography of the Igh locus, spatial distance distributions were determined between 12 genomic markers that span the entire Igh locus. Comparison of the distance distributions to computer simulations of alternative chromatin arrangements predic ...[more]