Ontology highlight
ABSTRACT:
SUBMITTER: Almutairi A
PROVIDER: S-EPMC2772156 | biostudies-literature | 2008 Nov-Dec
REPOSITORIES: biostudies-literature
Almutairi Adah A Akers Walter J WJ Berezin Mikhail Y MY Achilefu Samuel S Fréchet Jean M J JM
Molecular pharmaceutics 20081101 6
Synthetic polymers and dendrimers have been widely used by the medical community to overcome biological barriers and enhance in vivo biomedical applications. Despite the widespread use of biomaterials it has been generally extremely difficult to monitor noninvasively their fate in vivo. Here we report multilayered nanoprobes, consisting of a near-infrared core, nanoencapsulated in a biodegradable dendrimer, and surrounded by a shell of polyethylene oxide. Covalent encapsulation of the near-infra ...[more]