Ontology highlight
ABSTRACT:
SUBMITTER: Braun CR
PROVIDER: S-EPMC4890644 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Braun Craig R CR Bird Gregory H GH Wühr Martin M Erickson Brian K BK Rad Ramin R Walensky Loren D LD Gygi Steven P SP Haas Wilhelm W
Analytical chemistry 20150904 19
Isobaric labeling strategies for mass spectrometry-based proteomics enable multiplexed simultaneous quantification of samples and therefore substantially increase the sample throughput in proteomics. However, despite these benefits, current limits to multiplexing capacity are prohibitive for large sample sizes and impose limitations on experimental design. Here, we introduce a novel mechanism for increasing the multiplexing density of isobaric reagents. We present Combinatorial Isobaric Mass Tag ...[more]