Ontology highlight
ABSTRACT:
SUBMITTER: Silverman RB
PROVIDER: S-EPMC2775413 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20090906 21
Several prodrug approaches were taken to mask amino groups in two potent and selective neuronal nitric oxide synthase (nNOS) inhibitors containing either a primary or secondary amino group to lower the charge and improve blood-brain barrier (BBB) penetration. The primary amine was masked as an azide and the secondary amine as an amide or carbamate. The azide was not reduced to the amine under a variety of in vitro and ex vivo conditions. Despite the decrease in charge of the amino group as an am ...[more]