A bridge to transcription by RNA polymerase.
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ABSTRACT:
SUBMITTER: Kaplan CD
PROVIDER: S-EPMC2776398 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
A bridge to transcription by RNA polymerase.
Kaplan Craig D CD Kornberg Roger D RD
Journal of biology 20081202 10
A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'. ...[more]
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