Ontology highlight
ABSTRACT:
SUBMITTER: Pereira de Araujo AF
PROVIDER: S-EPMC2776435 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Pereira de Araujo Antonio F AF Onuchic José N JN
Proceedings of the National Academy of Sciences of the United States of America 20091026 45
Protein tertiary structures are known to be encoded in amino acid sequences, but the problem of structure prediction from sequence continues to be a challenge. With this question in mind, recent simulations have shown that atomic burials, as expressed by atom distances to the molecular geometrical center, are sufficiently informative for determining native conformations of small globular proteins. Here we use a simple computational experiment to estimate the amount of this required burial inform ...[more]