Ontology highlight
ABSTRACT:
SUBMITTER: Beal AM
PROVIDER: S-EPMC2778196 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Beal Allison M AM Anikeeva Nadia N Varma Rajat R Cameron Thomas O TO Vasiliver-Shamis Gaia G Norris Philip J PJ Dustin Michael L ML Sykulev Yuri Y
Immunity 20091001 4
Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the secretory domain. Both paths utilized the same intracellular molecular events, which have different spatial and temporal arrangements and are regulated by the kinetics of Ca(2+)-mediated signaling. Rapid signaling caused swift granule concentration near the microtubule-organizing center (MTOC) and subsequent delivery by the polarized MTOC direc ...[more]