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Pd/C-mediated synthesis of indoles in water.

ABSTRACT: We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.

SUBMITTER: Layek M 

PROVIDER: S-EPMC2779661 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Pd/C-mediated synthesis of indoles in water.

Layek Mohosin M   Lakshmi Udaya U   Kalita Dipak D   Barange Deepak Kumar DK   Islam Aminul A   Mukkanti K K   Pal Manojit M  

Beilstein journal of organic chemistry 20090923

We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction. ...[more]

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