Ontology highlight
ABSTRACT:
SUBMITTER: Barthel SR
PROVIDER: S-EPMC2780742 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Barthel Steven R SR Wiese Georg K GK Cho Jaehyung J Opperman Matthew J MJ Hays Danielle L DL Siddiqui Javed J Pienta Kenneth J KJ Furie Bruce B Dimitroff Charles J CJ
Proceedings of the National Academy of Sciences of the United States of America 20091104 46
How cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, yet essential step in metastasis. We postulate that the metastatic process involves discrete adhesive interactions between circulating cancer cells and microvascular endothelial cells. Sialyl Lewis X (sLe(X)) on prostate cancer (PCa) cells is thought to promote metastasis by mediating PCa cell binding to microvascular endothelial (E)-selectin. Yet, regulation of sLe(X) and related E-selectin lig ...[more]