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Caged ceramide 1-phosphate analogues: synthesis and properties.

ABSTRACT: Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400-500 nm was demonstrated by stimulation of macrophage cell proliferation.

SUBMITTER: Lankalapalli RS

PROVIDER: S-EPMC2782442 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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Caged ceramide 1-phosphate analogues: synthesis and properties.

Lankalapalli Ravi S RS Ouro Alberto A Arana Lide L Arana Lide L Gómez-Muñoz Antonio A Bittman Robert R

The Journal of organic chemistry 20091101 22

Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400-500 nm was demonstrated by stimulation of macrophage cell proliferation. ...[more]

PMID: 19908915

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