Ontology highlight
ABSTRACT:
SUBMITTER: Dai SY
PROVIDER: S-EPMC2782520 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Dai Susie Y SY Burris Thomas P TP Dodge Jeffrey A JA Montrose-Rafizadeh Chahrzad C Wang Yong Y Pascal Bruce D BD Chalmers Michael J MJ Griffin Patrick R PR
Biochemistry 20091001 40
Here we present the use of hydrogen-deuterium exchange (HDX) mass spectrometry in analyzing the estrogen receptor beta ligand binding domain (ERbeta LBD) in the absence and presence of a variety of chemical compounds with different binding modes and pharmacological properties. Previously, we reported the use of HDX as a method for predicting the tissue selectivity of ERalpha ligands. HDX profiles of ERalpha LBD in complex with ligand could differentiate compounds of the same chemotype. In contra ...[more]