Ontology highlight
ABSTRACT:
SUBMITTER: Sitkiewicz E
PROVIDER: S-EPMC3788119 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sitkiewicz Ewa E Tarnowski Krzysztof K Poznański Jarosław J Kulma Magdalena M Dadlez Michal M
PloS one 20131001 10
Activation of the receptor for advanced glycation end products (RAGE) leads to a chronic proinflammatory signal, affecting patients with a variety of diseases. Potentially beneficial modification of RAGE activity requires understanding the signal transduction mechanism at the molecular level. The ligand binding domain is structurally uncoupled from the cytoplasmic domain, suggesting receptor oligomerization is a requirement for receptor activation. In this study, we used hydrogen-deuterium excha ...[more]