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Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange.


ABSTRACT: Numerous self-assembling molecules have been synthesized aiming at mimicking both the structural and dynamic properties found in living systems. Here we show the application of hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to unravel the nanoscale organization and the structural dynamics of synthetic supramolecular polymers in water. We select benzene-1,3,5-tricarboxamide (BTA) derivatives that self-assemble in H2O to illustrate the strength of this technique for supramolecular polymers. The BTA structure has six exchangeable hydrogen atoms and we follow their exchange as a function of time after diluting the H2O solution with a 100-fold excess of D2O. The kinetic H/D exchange profiles reveal that these supramolecular polymers in water are dynamically diverse; a notion that has previously not been observed using other techniques. In addition, we report that small changes in the molecular structure can be used to control the dynamics of synthetic supramolecular polymers in water.

SUBMITTER: Lou X 

PROVIDER: S-EPMC5440672 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange.

Lou Xianwen X   Lafleur René P M RPM   Leenders Christianus M A CMA   Schoenmakers Sandra M C SMC   Matsumoto Nicholas M NM   Baker Matthew B MB   van Dongen Joost L J JLJ   Palmans Anja R A ARA   Meijer E W EW  

Nature communications 20170515


Numerous self-assembling molecules have been synthesized aiming at mimicking both the structural and dynamic properties found in living systems. Here we show the application of hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to unravel the nanoscale organization and the structural dynamics of synthetic supramolecular polymers in water. We select benzene-1,3,5-tricarboxamide (BTA) derivatives that self-assemble in H<sub>2</sub>O to illustrate the strength of this technique for supramolec  ...[more]

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