Ontology highlight
ABSTRACT:
SUBMITTER: De M
PROVIDER: S-EPMC2782604 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Nature chemistry 20090901 6
There is a direct correlation between protein levels and disease states in human serum, which makes it an attractive target for sensors and diagnostics. However, this is challenging because serum features more than 20,000 proteins, with an overall protein content greater than 1 mM. Here we report a sensor based on a hybrid synthetic-biomolecule that uses arrays of green fluorescent protein and nanoparticles to detect proteins at biorelevant concentrations in both buffer and human serum. Distinct ...[more]