Ontology highlight
ABSTRACT:
SUBMITTER: Mroz P
PROVIDER: S-EPMC2782654 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Mroz Pawel P Bhaumik Jayeeta J Dogutan Dilek K DK Aly Zarmeneh Z Kamal Zahra Z Khalid Laiqua L Kee Hooi Ling HL Bocian David F DF Holten Dewey D Lindsey Jonathan S JS Hamblin Michael R MR
Cancer letters 20090405 1
The in vitro photodynamic therapy activity of four imidazole-substituted metalloporphyrins has been studied using human (HeLa) and mouse (CT26) cancer cell lines: an anionic Zn porphyrin and a homologous series of three cationic Zn, Pd or InCl porphyrins. A dramatic difference in phototoxicity was found: Pd cationic>InCl cationic>Zn cationic>Zn anionic. HeLa cells were more susceptible than CT26 cells. Induction of apoptosis was demonstrated using a fluorescent caspase assay. The anionic Zn porp ...[more]