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Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

ABSTRACT: Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD®-Soluble and TLD-1433, which have ideal photophysical properties to act as PDT PSs. We highlight the important role played by the metal ions in the PS for PDT activity.

SUBMITTER: McFarland SA

PROVIDER: S-EPMC7237330 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

McFarland Sherri A SA Mandel Arkady A Dumoulin-White Roger R Gasser Gilles G

Current opinion in chemical biology 20191120

Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD®-Soluble and TLD-1433, ...[more]

PMID: 31759225

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