Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.
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ABSTRACT:
SUBMITTER: Kuang Y
PROVIDER: S-EPMC3525362 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.
Kuang Yunyan Y Sun Huabing H Blain J Craig JC Peng Xiaohua X
Chemistry (Weinheim an der Bergstrasse, Germany) 20120831 40
The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions. ...[more]
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