Ontology highlight
ABSTRACT:
SUBMITTER: Blois TM
PROVIDER: S-EPMC2790274 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Blois Tracy M TM Hong Heedeok H Kim Tae H TH Bowie James U JU
Journal of the American Chemical Society 20091001 39
The study of protein folding requires a method to drive unfolding, which is typically accomplished by altering solution conditions to favor the denatured state. This has the undesirable consequence that the molecular forces responsible for configuring the polypeptide chain are also changed. It would therefore be useful to develop methods that can drive unfolding without the need for destabilizing solvent conditions. Here we introduce a new method to accomplish this goal, which we call steric tra ...[more]