Ontology highlight
ABSTRACT:
SUBMITTER: Rivera GM
PROVIDER: S-EPMC2793683 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Rivera Gonzalo M GM Vasilescu Dan D Papayannopoulos Venizelos V Lim Wendell A WA Mayer Bruce J BJ
Molecular cell 20091101 3
Modulation of actin dynamics through the N-WASp/Arp2/3 pathway is important in cell locomotion, membrane trafficking, and pathogen infection. Here, we demonstrate that Nck is essential for actin remodeling stimulated by phosphatidylinositol 4,5 bisphosphate (PI(4,5)P(2)) and, conversely, that PI(4,5)P(2) is necessary for localized actin polymerization induced by Nck in vivo. Nck knockdown or knockout suppressed actin comets induced by phosphatidylinositol 5-kinase (PIP5K), and PIP5K stimulated t ...[more]