Ontology highlight
ABSTRACT:
SUBMITTER: Fyrst H
PROVIDER: S-EPMC2795098 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Fyrst Henrik H Oskouian Babak B Bandhuvula Padmavathi P Gong Yaqiong Y Byun Hoe Sup HS Bittman Robert R Lee Andrew R AR Saba Julie D JD
Cancer research 20091201 24
Sphingolipid metabolites regulate cell proliferation, migration, and stress responses. Alterations in sphingolipid metabolism have been proposed to contribute to carcinogenesis, cancer progression, and drug resistance. We identified a family of natural sphingolipids called sphingadienes and investigated their effects in colon cancer. We find that sphingadienes induce colon cancer cell death in vitro and prevent intestinal tumorigenesis in vivo. Sphingadienes exert their influence by blocking Akt ...[more]