Ontology highlight
ABSTRACT:
SUBMITTER: Yuan H
PROVIDER: S-EPMC5669571 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yuan Huairui H Li Ni N Fu Da D Ren Jiale J Hui Jingyi J Peng Junjie J Liu Yongfeng Y Qiu Tong T Jiang Min M Pan Qiang Q Han Ying Y Wang Xiaoming X Li Qintong Q Qin Jun J
The Journal of clinical investigation 20170821 9
The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse models of colorectal cancer (CRC). SETD2 was not required for intestinal homeostasis under steady state; however, upon irradiation, genetic inactivation of Setd2 in mouse intestinal epithelium facilit ...[more]