Identification of correlated genetic variants jointly associated with rheumatoid arthritis using ridge regression.
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ABSTRACT:
SUBMITTER: Sun YV
PROVIDER: S-EPMC2795968 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Identification of correlated genetic variants jointly associated with rheumatoid arthritis using ridge regression.
Sun Yan V YV Shedden Kerby A KA Zhu Ji J Choi Nam-Hee NH Kardia Sharon Lr SL
BMC proceedings 20091215
Using the North American Rheumatoid Arthritis Consortium genome-wide association dataset, we applied ridged, multiple least-squares regression to identify genetic variants with apparent unique contributions to variation of anti-cyclic citrullinated peptide (anti-CCP), a newly identified clinical risk factor for development of rheumatoid arthritis. Within a 2.7-Mbp region on chromosome 6 around the well studied HLA-DRB1 locus, ridge regression identified a single-nucleotide polymorphism that was ...[more]
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