Ontology highlight
ABSTRACT:
SUBMITTER: Raychaudhuri S
PROVIDER: S-EPMC3142887 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20091108 12
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide association studies (GWAS) of 3,393 cases and 12,462 controls. We used Gene Relationships Across Implicated Loci (GRAIL), a computational method that applies statistical text mining to PubMed abstracts, to score these 179 loci for functional relationships to genes in 16 established RA disease loci. We identified 22 loci w ...[more]