Ontology highlight
ABSTRACT:
SUBMITTER: Brown JM
PROVIDER: S-EPMC2796293 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Brown J Mark JM Chung Soonkyu S Sawyer Janet K JK Degirolamo Chiara C Alger Heather M HM Nguyen Tam M TM Zhu Xuewei X Duong My-Ngan MN Brown Amanda L AL Lord Caleb C Shah Ramesh R Davis Matthew A MA Kelley Kathryn K Wilson Martha D MD Madenspacher Jennifer J Fessler Michael B MB Parks John S JS Rudel Lawrence L LL
Arteriosclerosis, thrombosis, and vascular biology 20091015 1
<h4>Background</h4>Stearoyl-CoA desaturase 1 (SCD1) is a critical regulator of energy metabolism and inflammation. We have previously reported that inhibition of SCD1 in hyperlipidemic mice fed a saturated fatty acid (SFA)-enriched diet prevented development of the metabolic syndrome, yet surprisingly promoted severe atherosclerosis. In this study we tested whether dietary fish oil supplementation could prevent the accelerated atherosclerosis caused by SCD1 inhibition.<h4>Methods and results</h4 ...[more]