Ontology highlight
ABSTRACT:
SUBMITTER: Panwar AS
PROVIDER: S-EPMC2797554 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20091201 51
We present a Langevin dynamics simulation study of enzyme-modulated translocation of a single-stranded DNA molecule through a cylindrical nanopore. The toroidal-shaped enzyme placed along the axis of the pore, threads a DNA molecule at a constant rate. As a result of this controlled release process, the length of DNA available for translocation varies with time. We examine the effect of time-dependent conformational entropy of the DNA on the translocation process. In addition, we also examine th ...[more]