Ontology highlight
ABSTRACT:
SUBMITTER: Liachko N
PROVIDER: S-EPMC2804473 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Liachko Nicole N Davidowitz Rachel R Lee Siu Sylvia SS
Developmental biology 20081207 1
Insulin/IGF-signaling (IIS) affects longevity, stress resistance and metabolism in worms, flies, and mammals. The Forkhead transcription factor DAF-16/FOXO is the major downstream effector of IIS and is responsible for the activation and repression of genes that mediate the diverse effects of IIS. We surveyed a set of informatically predicted conserved DAF-16/FOXO target genes and identified the novel DAF-16 direct target hlh-13. hlh-13 is the predicted homolog of the mammalian transcription fac ...[more]