DSir2 mediates the increased spontaneous physical activity in flies on calorie restriction.
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ABSTRACT:
SUBMITTER: Parashar V
PROVIDER: S-EPMC2806034 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction.
Parashar Vijay V Rogina Blanka B
Aging 20090622 6
Calorie restriction (CR) is the most effective way to increase life span and delay the onset of age-related symptoms in animals. We have previously reported that CR affects a variety of physiological phenotypes in flies and results in dramatic behavioral, physical and demographic changes. Here we show effects of low and high calorie levels on the spontaneous physical activity of flies. Wild type flies maintained on a low calorie diet exhibit higher spontaneous activity compared to flies on highe ...[more]
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