Ontology highlight
ABSTRACT:
SUBMITTER: Arendt KL
PROVIDER: S-EPMC2810846 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nature neuroscience 20091213 1
Despite their low abundance, phosphoinositides are critical regulators of intracellular signaling and membrane compartmentalization. However, little is known of phosphoinositide function at the postsynaptic membrane. Here we show that continuous synthesis and availability of phosphatidylinositol-(3,4,5)-trisphosphate (PIP(3)) at the postsynaptic terminal is necessary for sustaining synaptic function in rat hippocampal neurons. This requirement was specific for synaptic, but not extrasynaptic, AM ...[more]