Ontology highlight
ABSTRACT:
SUBMITTER: Cunha SI
PROVIDER: S-EPMC2812548 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Cunha Sara I SI Pardali Evangelia E Thorikay Midory M Anderberg Charlotte C Hawinkels Lukas L Goumans Marie-José MJ Seehra Jasbir J Heldin Carl-Henrik CH ten Dijke Peter P Pietras Kristian K
The Journal of experimental medicine 20100111 1
Members of the transforming growth factor beta (TGF-beta) family have been genetically linked to vascular formation during embryogenesis. However, contradictory studies about the role of TGF-beta and other family members with reported vascular functions, such as bone morphogenetic protein (BMP) 9, in physiological and pathological angiogenesis make the need for mechanistic studies apparent. We demonstrate, by genetic and pharmacological means, that the TGF-beta and BMP9 receptor activin receptor ...[more]