Ontology highlight
ABSTRACT:
SUBMITTER: Salome C
PROVIDER: S-EPMC2818974 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100201 3
The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent (R)-lacosamide [(R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-3] has been explored. Forty-three compounds were prepared and then evaluated at the National Institute of Neurological Disorders and Stroke Anticonvulsant Screening Program for seizure protection in the maximal electroshock (MES) and subcutaneous Metrazol models. Comparing activities for two series of substituted aryl regioisomer ...[more]