Ontology highlight
ABSTRACT:
SUBMITTER: Macpherson IS
PROVIDER: S-EPMC2819028 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Macpherson Iain S IS Kirubakaran Sivapriya S Gorla Suresh Kumar SK Riera Thomas V TV D'Aquino J Alejandro JA Zhang Minjia M Cuny Gregory D GD Hedstrom Lizbeth L
Journal of the American Chemical Society 20100201 4
Cryptosporidium parvum is a potential biowarfare agent, an important AIDS pathogen, and a major cause of diarrhea and malnutrition. No vaccines or effective drug treatment exist to combat Cryptosporidium infection. This parasite relies on inosine 5'-monophosphate dehydrogenase (IMPDH) to obtain guanine nucleotides, and inhibition of this enzyme blocks parasite proliferation. Here, we report the first crystal structures of CpIMPDH. These structures reveal the structural basis of inhibitor selecti ...[more]