Ontology highlight
ABSTRACT:
SUBMITTER: Salem ML
PROVIDER: S-EPMC2821961 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Salem Mohamed L ML El-Naggar Sabry A SA Cole David J DJ
Cellular immunology 20091205 2
We have shown recently that cyclophosphamide (CTX) treatment induced a marked increase in the numbers of immature dendritic cells (DCs) in blood, coinciding with enhanced antigen-specific responses of the adoptively transferred CD8(+) T cells. Because this DC expansion was preceded by DC proliferation in bone marrow (BM), we tested whether BM post CTX treatment can generate higher numbers of functional DCs. BM was harvested three days after treatment of C57BL/6 mice with PBS or CTX and cultured ...[more]