Ontology highlight
ABSTRACT:
SUBMITTER: Gall VA
PROVIDER: S-EPMC5626640 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gall Victor A VA Philips Anne V AV Qiao Na N Clise-Dwyer Karen K Perakis Alexander A AA Zhang Mao M Clifton Guy T GT Sukhumalchandra Pariya P Ma Qing Q Reddy Sangeetha M SM Yu Dihua D Molldrem Jeffrey J JJ Peoples George E GE Alatrash Gheath G Mittendorf Elizabeth A EA
Cancer research 20170817 19
Early-phase clinical trials evaluating CD8<sup>+</sup> T cell-eliciting, HER2-derived peptide vaccines administered to HER2<sup>+</sup> breast cancer patients in the adjuvant setting suggest synergy between the vaccines and trastuzumab, the mAb targeting the HER2 protein. Among 60 patients enrolled in clinical trials evaluating the E75 + GM-CSF and GP2 + GM-CSF vaccines, there have been no recurrences in patients vaccinated after receiving trastuzumab as part of standard therapy in the per treat ...[more]