Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC2823563 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Sun Huaqin H Li Dan D Chen Shu S Liu Yanyan Y Liao Xiaolin X Deng Wenqian W Li Na N Zeng Mei M Tao Dachang D Ma Yongxin Y
The Journal of biological chemistry 20091209 6
Piwi proteins are required for germ cell proliferation, differentiation, and germ line stem cell maintenance. In normal tissues, human and mouse Piwil2 are primarily expressed in testis but widely expressed in tumors. However, the underlying mechanism remains largely unknown. In vertebrates, transforming growth factor (TGF)-beta signaling plays an important role in patterning embryo and control of cell growth and differentiation. A previous study has shown a role for Zili, a Piwil2 gene in zebra ...[more]