Ontology highlight
ABSTRACT:
SUBMITTER: Ito I
PROVIDER: S-EPMC2863224 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Ito Ichiaki I Hanyu Aki A Wayama Mitsutoshi M Goto Natsuka N Katsuno Yoko Y Kawasaki Shohei S Nakajima Yuka Y Kajiro Masashi M Komatsu Yoko Y Fujimura Akiko A Hirota Ryuichi R Murayama Akiko A Kimura Keiji K Imamura Takeshi T Yanagisawa Junn J
The Journal of biological chemistry 20100305 19
Estrogen is a growth factor that stimulates cell proliferation. The effects of estrogen are mediated through the estrogen receptors, ERalpha and ERbeta, which function as ligand-induced transcription factors and belong to the nuclear receptor superfamily. On the other hand, TGF-beta acts as a cell growth inhibitor, and its signaling is transduced by Smads. Although a number of studies have been made on the cross-talk between estrogen/ERalpha and TGF-beta/Smad signaling, whose molecular mechanism ...[more]