Serum deprivation response inhibits breast cancer progression by blocking transforming growth factor-? signaling.
Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC4814251 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Serum deprivation response inhibits breast cancer progression by blocking transforming growth factor-β signaling.
Tian Yao Y Yu Yue Y Hou Li-Kun LK Chi Jiang-Rui JR Mao Jie-Fei JF Xia Li L Wang Xin X Wang Ping P Cao Xu-Chen XC
Cancer science 20160213 3
Serum deprivation response (SDPR), a key substrate for protein kinase C, play a critical role in inducing membrane curvature and participate in the formation of caveolae. However, the function of SDPR in cancer development and progression is still not clear. Here, we found that SDPR is downregulated in human breast cancer. Overexpression of SDPR suppresses cell proliferation and invasion in MDA-MB-231 cells, while depletion of SDPR promotes cell proliferation and invasion in MCF10A cells. Subseq ...[more]
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