Ontology highlight
ABSTRACT:
SUBMITTER: Cope DW
PROVIDER: S-EPMC2824149 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nature medicine 20091122 12
The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired gamma-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABA(A) receptor-dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA up ...[more]