Ontology highlight
ABSTRACT:
SUBMITTER: Abramian AM
PROVIDER: S-EPMC3009907 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20101012 53
Tonic inhibition in the brain is mediated largely by specialized populations of extrasynaptic receptors, γ-aminobutyric acid receptors (GABA(A)Rs). In the dentate gyrus region of the hippocampus, tonic inhibition is mediated primarily by GABA(A)R subtypes assembled from α4β2/3 with or without the δ subunit. Although the gating of these receptors is subject to dynamic modulation by agents such as anesthetics, barbiturates, and neurosteroids, the cellular mechanisms neurons use to regulate their a ...[more]