Ontology highlight
ABSTRACT:
SUBMITTER: Tan C
PROVIDER: S-EPMC2826894 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Tan Chibing C Dlugosz Paulina J PJ Peng Jun J Zhang Zhi Z Lapolla Suzanne M SM Plafker Scott M SM Andrews David W DW Lin Jialing J
The Journal of biological chemistry 20060329 21
Interactions among Bcl-2 family proteins mediated by Bcl-2 homology (BH) regions transform apoptosis signals into actions. The interactions between BH3 region-only proteins and multi-BH region proteins such as Bax and Bcl-2 have been proposed to be the dominant interactions required for initiating apoptosis. Experimental evidence also suggests that both homo- and hetero-interactions are mediated primarily by the BH3 regions in all Bcl-2 family proteins and contribute to commitment to or inhibiti ...[more]