Ontology highlight
ABSTRACT:
SUBMITTER: O'Neill KL
PROVIDER: S-EPMC4840302 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
O'Neill Katelyn L KL Huang Kai K Zhang Jingjing J Chen Yi Y Luo Xu X
Genes & development 20160407 8
The mechanism of Bax/Bak activation remains a central question in mitochondria-dependent apoptotic signaling. While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only proteins bind and neutralize the anti-apoptotic Bcl-2 family proteins, how this neutralization leads to Bax/Bak activation has been actively debated. Here, genome editing was used to generate cells deficient for all eight proapoptotic BH3-only proteins (OctaKO) and those that lack the entire Bcl-2 family (Bcl-2 all ...[more]