Ontology highlight
ABSTRACT:
SUBMITTER: Rihel J
PROVIDER: S-EPMC2830481 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Rihel Jason J Prober David A DA Arvanites Anthony A Lam Kelvin K Zimmerman Steven S Jang Sumin S Haggarty Stephen J SJ Kokel David D Rubin Lee L LL Peterson Randall T RT Schier Alexander F AF
Science (New York, N.Y.) 20100101 5963
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors. Behavioral profiling revealed conserved functions of psychotropic molecules and p ...[more]