Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish.
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ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC5653285 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish.
Chen Shijia S Reichert Sabine S Singh Chanpreet C Oikonomou Grigorios G Rihel Jason J Prober David A DA
Neuron 20170622 1
Light affects sleep and wake behaviors by providing an indirect cue that entrains circadian rhythms and also by inducing a direct and rapid regulation of behavior. While circadian entrainment by light is well characterized at the molecular level, mechanisms that underlie the direct effect of light on behavior are largely unknown. In zebrafish, a diurnal vertebrate, we found that both overexpression and mutation of the neuropeptide prokineticin 2 (Prok2) affect sleep and wake behaviors in a light ...[more]
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