Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC2830698 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Lee Ji-Hoon JH Goodarzi Aaron A AA Jeggo Penny A PA Paull Tanya T TT
The EMBO journal 20091210 3
The Mre11/Rad50/Nbs1 (MRN) complex has a central function in facilitating activation of the ATM protein kinase at sites of DNA double-strand breaks (DSBs). However, several other factors are also required in human cells for efficient signalling through MRN and ATM, including the tumour suppressor proteins p53-binding protein 1 (53BP1) and BRCA1. In this study, we investigate the functions of these mediator proteins in ATM activation and find that the presence of 53BP1 and BRCA1 can amplify the e ...[more]