Ontology highlight
ABSTRACT:
SUBMITTER: Tikhmyanova N
PROVIDER: S-EPMC2836406 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Tikhmyanova Nadezhda N Little Joy L JL Golemis Erica A EA
Cellular and molecular life sciences : CMLS 20091125 7
Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology. CAS proteins act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and have more recently been linked to a role in progenitor cell function. Reflecting these complex functions, over-expression of CAS proteins has now been strongly linked to poor progn ...[more]