Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
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ABSTRACT:
SUBMITTER: Park EJ
PROVIDER: S-EPMC2836922 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
Park Eek Joong EJ Lee Jun Hee JH Yu Guann-Yi GY He Guobin G Ali Syed Raza SR Holzer Ryan G RG Osterreicher Christoph H CH Takahashi Hiroyuki H Karin Michael M
Cell 20100101 2
Epidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and development, we focused on hepatocellular carcinoma (HCC), the common form of liver cancer whose occurrence and progression are the most strongly affected by obesity among all cancers. We now demonstrate that either dietary or genetic obesity is a potent bona fide liver tumor promoter in mice. Obesity-promoted HCC development was dependent on enhan ...[more]
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