Ontology highlight
ABSTRACT:
SUBMITTER: Nickerson DP
PROVIDER: S-EPMC2836955 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Nickerson Daniel P DP West Matthew M Henry Ryan R Odorizzi Greg G
Molecular biology of the cell 20100120 6
Recruitment of endosomal sorting complexes required for transport (ESCRTs) to the cytosolic face of endosomes regulates selective inclusion of transmembrane proteins into the lumenal vesicles of multivesicular bodies (MVBs). ESCRT-0, -I, and -II bind directly to ubiquitinated transmembrane cargoes of the MVB pathway, whereas polymerization of ESCRT-III at endosomes is thought to bend the membrane and/or provide the energetic force that drives membrane scission and detachment of vesicles into the ...[more]