Ontology highlight
ABSTRACT:
SUBMITTER: Talbot GE
PROVIDER: S-EPMC2839432 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Talbot Gillian E GE Waddington Simon N SN Bales Olivia O Tchen Rose C RC Antoniou Michael N MN
Molecular therapy : the journal of the American Society of Gene Therapy 20091124 3
Lentiviral vectors (LVs) are highly attractive as a gene therapy agent as they are able to stably integrate their genomes in both dividing and nondividing cells and, in principle, provide long-term therapeutic benefit. However, their performance in skeletal muscle in adult animals has, to date, been disappointing. In order to gain clearer insight into their utility in this tissue type, we have conducted an extensive quantitative comparison of constitutive and muscle-specific promoter activities ...[more]