Ontology highlight
ABSTRACT:
SUBMITTER: Frank AM
PROVIDER: S-EPMC6216101 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Frank Annika M AM Buchholz Christian J CJ
Molecular therapy. Methods & clinical development 20181017
Lymphocytes have always been among the prime targets in gene therapy, even more so since chimeric antigen receptor (CAR) T cells have reached the clinic. However, other gene therapeutic approaches hold great promise as well. The first part of this review provides an overview of current strategies in lymphocyte gene therapy. The second part highlights the importance of precise gene delivery into B and T cells as well as distinct subtypes of lymphocytes. This can be achieved with lentiviral vector ...[more]