Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki A
PROVIDER: S-EPMC2840499 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Suzuki Atsushi A Igarashi Katsuhide K Aisaki Ken-Ichi K Kanno Jun J Saga Yumiko Y
Proceedings of the National Academy of Sciences of the United States of America 20100202 8
Nanos is one of the evolutionarily conserved proteins implicated in germ cell development. We have previously shown that NANOS2 plays an important role in both the maintenance and sexual development of germ cells. However, the molecular mechanisms underlying these events have remained elusive. In our present study, we found that NANOS2 localizes to the P-bodies, known centers of RNA degradation that are abundantly accumulated in male gonocytes. We further identified by immunoprecipitation that t ...[more]