Orientation and dynamics of transmembrane peptides: the power of simple models.
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ABSTRACT:
SUBMITTER: Holt A
PROVIDER: S-EPMC2841270 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Orientation and dynamics of transmembrane peptides: the power of simple models.
Holt Andrea A Killian J Antoinette JA
European biophysics journal : EBJ 20091218 4
In this review we discuss recent insights obtained from well-characterized model systems into the factors that determine the orientation and tilt angles of transmembrane peptides in lipid bilayers. We will compare tilt angles of synthetic peptides with those of natural peptides and proteins, and we will discuss how tilt can be modulated by hydrophobic mismatch between the thickness of the bilayer and the length of the membrane spanning part of the peptide or protein. In particular, we will focus ...[more]
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